DNA SCRIPT – Purification Technician – Fermentation Technician
Job description
Opportunity and Challenges
We are looking to assemble a team of best-in-class, innovative and passionately impatient people. We want to gather their talents and skills to achieve one goal: unlock the power of “DNA-write.” We offer the opportunity of joining a dynamic, international, and highly skilled team in a pioneering startup. Our DNA On Demand platform not only has the potential to change the way the world makes and uses synthetic DNA, but also to accelerate the rate of discovery by delivering upon the promise of same-day results.
This is an opportunity to join a rapidly growing company and to have a large impact on developing a technology that will have far-reaching impacts across biological sciences.
Purification Technician (M/F) – Enzyme Manufacturing
The Purification technician will be working in the enzyme manufacturing team to conduct internal production of our proprietary enzymes, one of the key reagents in DNA Script’s technology. Under general supervision of the Enzyme Manufacturing Manager and following written work instruction, you will be in charge of the weekly batch purification of enzymes and IPC (In Process Control). You will have also to perform other laboratory tasks assigned.
Responsibilities
- Production of enzymes according to work instruction (WI) and manufacturing batch record (MBR)
o DSP stream tasks include HPLC, concentration, formulation and aliquoting - Preparing equipment by performing cleaning-in-place (CIP) and manual cleaning.
- Preparing buffers in accordance with procedures.
- Monitoring of in process purification
- Initiating deviations as needed, reporting and solving problems and issues under manager guidance
- Performing IPC assays in accordance with test methods
- Maintaining detailed documentation of all work process
- Participating in manufacturing team meeting and presenting technical report
Preferred experience
Essential
- Holds a bachelor’s degree in the field of Biotechnology, Chemical Engineering or related fields
- Minimum 3+ years of industrial / manufacturing experience
- Experience with AKTA systems and UNICORN software
- Good biochemistry knowledge
- Strong record keeping skills
- Good organizational skills
- Ability to work independently and in a team environment
- Good organizational skill
Desirable
- Experience in purification of recombinant proteins
- Good level in English (speaking, reading and writing reports)
- Experience in ERP system (NetSuite / Oracle) and QMS
Recruitment process
- Visio interview with the hiring manager
- Day interview at the office with the manager, cofounders, HR and the rest of the team
- Reference Checks
- Timing: 2-3 weeks
The Role : Fermentation Technician (M/F) – Enzyme Manufacturing
The Fermentation technician will be working in the enzyme manufacturing team to conduct internal production of our proprietary enzymes, one of the key reagents in DNA Script’s technology. Under general supervision of the Enzyme Manufacturing Manager and following written work instruction, your task will be to conduct the enzyme production in bioreactor from 5L to 150L scale and some downstream processing operations (harvesting, lysis, clarification). You will have also to perform other laboratory tasks assigned.
Main Responsibilities
- Production of enzymes according to work instruction (WI) and manufacturing batch record (MBR)
- o Upstream tasks include transformation, subculture, cell banking, shake flask growth, fermentation, cell harvest, lysis, clarification
- Preparing equipment by performing cleaning-in-place (CIP), steaming-in-place (SIP), and manual cleaning.
- Preparing media, feeds, and buffers in accordance with procedures.
- Monitoring of in process fermentation
- Initiating deviations as needed, reporting and solving problems and issues under manager guidance
- Performing various QC assays in accordance with test methods
- Maintaining detailed documentation of all work process
- Participating in manufacturing team meeting and presenting technical report
- Maintaining laboratory safety practice
Preferred experience
Essential
- Holds a bachelor’s degree in the field of Biotechnology, Chemical Engineering or related fields
- Minimum 3+ years of industrial / manufacturing experience
- Be able to set up and run bioreactor in batch and fed-batch mode
- Strong record keeping skills
- Ability to work independently and in a team environment
- Good organizational skill
Desirable
- Experience in production of recombinant proteins
- Good level in English (speaking, reading and writing reports)
- Experience in ERP (NetSuite / Oracle) system and QMS
Recruitment process
- Visio interview with the hiring manager
- Day interview at the office with the manager, cofounders, HR and the rest of the team
- Reference Checks
- Timing: 2-3 weeks
Contact: pour obtenir des précisions sur cette offre et les coordonnées de la personne en charge de cette offre, envoyez un email à cathy.guilbot@estba.org , en précisant vos nom et prénom ainsi que le nom et l’année de la formation que vous avez suivie à l’ESTBA.